Rafa Marquez scored on a header in the 89th minute, and Mexico nipped the United States 2-1. That’s the Americans’ first home loss in World Cup qualifying since 2001.

Miguel Layun put Mexico ahead in the 20th minute, but Bobby Wood tied the score in the 49th.

The U.S. dominated the second half before the 37-year-old Marquez scored late against goalkeeper Brad Guzan.

Guzan lost the goalkeeper job to Tim Howard, who started at the last two World Cups. But Howard injured his right leg on a goal kick and was replaced in the 40th minute.

The U.S. had beaten Mexico four straight times by 2-0 scores in home qualifiers.